Synthesizing Peptides In India Using Solid Phase Method

 

A topic of increasing interest in science today is custom peptide synthesis in India. This is beneficial for many applications such as drug delivery and sensor components.

Peptides play important roles in fundamental biochemical and physiological processes and are essential to many aspects of biomedical research, especially as the pharmaceutical industry continues to develop new drug candidates in the biological realm. Therefore, fast, efficient and reliable methodologies for chemical peptide synthesis in India are of utmost interest in chemical biology research.

A brief insight into solid phase peptide synthesis(SPPS)

Generally, peptide drugs are chemically synthesized by attaching the carboxyl group of an amino acid to the N-terminus of a growing peptide chain. Due to the complex nature of in vitro protein synthesis, amino acids are added stepwise and cyclically to the growing peptide chain. Although some important differences exist in commonly used peptide synthesis methods, they all follow the same method of amino acid addition. With the advent of solid-phase peptide synthesis, the synthesis of long peptides has become easier, more efficient and more accessible. 

Why does a  peptide synthesis company in India stress on SPPS process? 

SPPS is the most preferred technique for the chemical synthesis of peptides, allowing the use of automation to perform peptide synthesis while facilitating multiple post-translational backbone modifications and insertion of unnatural amino acids. This approach avoids the relatively time-consuming separation of the product peptide from the solution after each reaction step and opens the door to automation. This is because subsequent couplings can be performed iteratively through a defined set of unit operations. As a result, many challenging peptides have been successfully synthesised using the SPPS approach.

The advent of solid-phase technology has accelerated the synthesis of peptide pharmaceuticals in today's drug discovery and development. The application of high-quality chemically synthesized peptides has become popular due to the development of biotechnology. Additionally, peptide synthesis techniques and for many research purposes such as cancer diagnosis and therapy, antibiotic development, epitope mapping, and antibody and vaccine production.

Conclusion

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